Tunable catalytic release of nitric oxide via copper‐loaded coatings on titanium nanotubes for regulating biological performance

Severe lesions in vessels need to be treated with implantable interventional devices such as vascular stents, which should anti-coagulantion, anti-proliferation and promoting endothelialisation. Nitric oxide (NO), a physiological gas signalling molecule, play an important role revascularisation. Catalysing the release of NO from endogenous donors has already been widely favoured treatment strategy for lesioned vessels. In this work, series copper-loaded coatings (titanium nanotube (TNT)/PDA-Cu) was fabricated by TNTs combined polydopamine ions, achieve controlled situ catalytic NO. This could effectively immobilised copper ions on TNTs, promoted proliferation endothelial cells inhibited growth smooth muscle (SMCs) via performance NO, well restrain platelet adhesion. With multiple function, TNT/PDA-Cu provides promise approach endothelialisation, anti-coagulation inhibition SMC TNTs.